How to pronounce“overalkylation”in English

Problem two is overalkylation: on the flip side to our alkylation reactions not working at all, they can also work almost too well.

I know I said that overalkylation can be a problem sometimes, but an overalkylated amine can be useful, too!

Luckily for us, the solution to overalkylation is simple: use our other Friedel-Crafts reaction.

They have some advantages over enolates, because we usually don't have to worry about overalkylation!

In Episode 39, we learned how to work around both overalkylation and rearrangement using a Friedel-Crafts acylation reaction.

By introducing the deactivating acyl group, we avoid the overalkylation issue.