How to pronounce“amides”in English

instant alkyl amides these days secretary for agitation and propaganda

So that's why amides are the least reactive of the quartet, with the weakest inductive effects and strongest resonance effects.

For esters and amides, though, the reaction with water alone is too slow.

I know we've said that amides are the least reactive of our four carboxylic acid derivatives, but the ring strain from the four-membered ring makes this amide super easy to hydrolyze.

And it’s a similar story with amides.

Remember that esters are more reactive than amides as functional groups on carboxylic acid derivatives, so the ester hydrolysis reaction will probably happen before the amide hydrolysis.

Base-catalyzed hydrolysis is possible with amides, but this requires a strong base and lots of heating.